第一段先说TLR对抗原呈递从而抗癌有益，而且TLR4被干掉以后不利于治疗癌症，然后到了第二段又说与预期的一样，TLR相关的一个基因被干掉之后更抗癌了
这个逻辑看不懂啊，因为我们知道TLR抗癌，所以可以预期破坏TLR通路可以抗癌……这是神马逻辑……

@Lucy赤い月 @尼龙菌 @雪印制糖

这咋就话题了……

回复 0o剑雨浮生o0 :好像有点儿道理，不过那也不用说正如预期吧……而且炎症诱导癌症不要说的好像天经地义一样……

Back to Coley: a 21st century perspective.
We now realize that Coley’s mixed
toxins must have been powerful stimulants
of TLRs140, inducing a range of inflammatory
mediators, not just TNF. The closest recent
approximation to Coley’s work is probably
the successful local treatment of bladder
cancer with bacillus Calmette–Guerin141.
Current thinking is that both bacillus
Calmette–Guerin and Coley’s toxins trigger
a desirable inflammatory response, through
TLRs, that not only stimulates macrophages
to kill tumour cells but also promotes the
development of sustained and effective adaptive
immunity to the tumour142. This type of
response may also contribute to successful
Back to Coley: a 21st century perspective.
We now realize that Coley’s mixed
toxins must have been powerful stimulants
of TLRs140, inducing a range of inflammatory
mediators, not just TNF. The closest recent
approximation to Coley’s work is probably
the successful local treatment of bladder
cancer with bacillus Calmette–Guerin141.
Current thinking is that both bacillus
Calmette–Guerin and Coley’s toxins trigger
a desirable inflammatory response, through
TLRs, that not only stimulates macrophages
to kill tumour cells but also promotes the
development of sustained and effective adaptive
immunity to the tumour142. This type of
response may also contribute to successful