level 8
我要翻译段很复杂的文章所以我想问大家有人可以帮我翻译下吗真的很难我现在先放一点...帮我下,谢谢very much了TT在这拜谢了救命啊!!
2008年05月27日 03点05分
1
level 8
The sensations of bitter and sweet tastes are initiated by theinteraction of sapid molecules (“tastants”) with G protein-coupledreceptors (GPCRs)1 in the apical membranes of taste receptorcells (TRCs). TRCs are specialized epithelial cells withmany neuronal properties including the ability to depolarizeand form synapses. TRCs are typically clustered in groups of100 within taste buds. The apical surface of TRCs, whichmakes contact with the oral cavity, is rich in convoluted microvillicontaining GPCRs, ion channels, and other transductionelements. The basolateral aspect of TRCs contains ionchannels and synapses with afferent taste nerves.第2段谢谢亲们了啊,爱你们
2008年05月27日 04点05分
31
level 8
这篇翻译啊毕业论文要交的谢谢亲们帮忙还有很多呢我在线翻译很多都不通的句子
2008年05月27日 04点05分
32
level 8
2.The sensations of bitter and sweet tastes are initiated by the interaction of sapid molecules (“tastants”) with G protein-coupled receptors (GPCRs)1 in the apical membranes of taste receptor cells (TRCs). TRCs are specialized epithelial cells with many neuronal properties including the ability to depolarize and form synapses. TRCs are typically clustered in groups of 100 within taste buds. The apical surface of TRCs, which makes contact with the oral cavity, is rich in convoluted microvilli containing GPCRs, ion channels, and other transduction elements. The basolateral aspect of TRCs contains ion channels and synapses with afferent taste nerves.
2008年05月27日 04点05分
33
level 8
Bitter TransductionReceptors—“Data mining” of the National Center for Biotechnology3.Information DNA sequence data bases was used toidentify an 25-member multigene family of TRC-expressedGPCRs, named T2Rs or TRBs (so-called as the second family oftaste receptors identified) (1, 2). The T2R/TRB GPCRs map toregions of human and mouse chromosomes implicated geneticallyin sensitivity to various bitter compounds (3–5). T2R/TRBreceptors are only distantly related to other GPCRs such as theV1R vomeronasal receptors and display 30–70% identity within the gene family. These receptors have the greatest conservationin their cytoplasmic loops and their adjacent transmembranesegments (predicted sites of G protein interaction)and the greatest divergence in their extracellular regions (potentialregions of ligand binding).
2008年05月27日 06点05分
37
level 8
3.Bitter TransductionReceptors—“Data mining” of the National Center for BiotechnologyInformation DNA sequence data bases was used toidentify an 25-member multigene family of TRC-expressedGPCRs, named T2Rs or TRBs (so-called as the second family oftaste receptors identified) (1, 2). The T2R/TRB GPCRs map toregions of human and mouse chromosomes implicated geneticallyin sensitivity to various bitter compounds (3–5). T2R/TRBreceptors are only distantly related to other GPCRs such as theV1R vomeronasal receptors and display 30–70% identity within the gene family. These receptors have the greatest conservationin their cytoplasmic loops and their adjacent transmembranesegments (predicted sites of G protein interaction)and the greatest divergence in their extracellular regions (potentialregions of ligand binding).
2008年05月27日 06点05分
38
level 8
4.In rat and mouse T2R/TRB receptors are expressed in 15–20% of TRCs in taste buds of the circumvallate and foliatepapillae and the palate but in very few TRCs in fungiformpapillae (1). Based on in situ hybridization with mixed versusindividual T2R/TRB probes it was concluded that most T2R/TRB receptors are expressed in the same TRCs (1, 2). T2R/TRBreceptors are only found in TRCs positive for expression ofgustducin (a G protein implicated in bitter taste) (see Fig. 2)(1).
2008年05月27日 06点05分
41
level 8
5.One murine T2R/TRB receptor (mT2R5), when expressed inheterologous cells, responded to bitter cycloheximide at a concentrationcomparable with the murine threshold for aversion(6). mT2R5 was found to couple selectively to -gustducin versusother G protein -subunits. Taste responses were obtainedfrom only one other T2R/TRB-transfected cell; a human/mouseorthologous pair, hT2R4/mT2R8, apparently encodes a receptorresponsive to denatonium and 6-n-propyl-2-thiouracil. However,the concentration of denatonium required to stimulatethis receptor was more than 3 orders of magnitude higher thanthe human threshold for detection, suggesting that anotherGPCR is likely to be the “denatonium” receptor.
2008年05月27日 06点05分
48