黑色为已完成的，红色是预计可能产生或者失败的产物.
路线从1开始，6是目标产物。路线一在氨基变巯基时走不下去了，使用重氮化时候加酸，结果得到了对位环合产物。路线2到了8.好吧就想问e神1到6有没有比较好的合成方法。。。

to the failures, do you ever know why it failed? have you ever tried other conditions?
You first need to know about those and then try to optimize the condition, do better literature search and after all of these, if you still can*t make it work, you can consider of changing the overall strategy. By then, I may offer you help if I have time.
This is for now what I can give you. My boss would suggest the same thing in this situation.

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2楼讲的话没什么实际意义吧。。改变环境和策略什么的

In my view, a functioning professional researcher (i.e. Ph.D.) is a self-sufficient scientist who is capable of identifying an interesting problem to study, can design a plan of investigation, has the technical expertise to execute many different kinds of experiments, can interpret their results, formulate reasonable hypotheses, and draw sensible conclusions about the success of the work. This individual is also capable of writing up and orally presenting the work they have completed. To develop these abilities, a student must first become technically proficient, must know the chemical literature in their own research area as well as those tangential to the project, must learn how to decide what the results mean and develop analytical skills to formulate working hypotheses from a large body of empirical data. In time, the student will also learn the distinction between truly innovative research and research that is incremental or derivative. Finally, the student should make an original contribution to science and be able to see opportunities for new studies in creative directions.
--S.E.Denmark

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7到3不知道楼主是怎么想的，失败了就算了，红色部分还设计出类似的反应，6还少画了双键，怪不得e神要发denmark那段话